Size:
Active Ingredient: Toltrazuril
Target Species: Calves, Lambs, Piglets
Treats and Controls: Coccidiosis
Administration Method: Oral drench
Withdrawal Time: Withdrawal period for meat and offal in calves is 63 days; Piglets 77 days; lambs 42 days Do not use in animals producing milk for human consumption.
Dosage: Piglets and lambs - 0.4 ml oral dose per kg. Calves - 3 ml per 10kg.
Dosage Rates For Piglets/Lambs | |||
Body Weight | Dose Volume | Number of full doses per pack: | |
250 ML | 1 L | ||
10kg | 4 ml | 62 | 250 |
20kg | 8 ml | 31 | 125 |
30kg | 12 ml | 20 | 83 |
40kg | 16 ml | 15 | 62 |
50kg | 20 ml | 12 | 50 |
60kg | 24 ml | 10 | 41 |
70kg | 28 ml | 8 | 35 |
Dosage Rates For Calves | |||
Body Weight | Dose Volume | Number of full doses per pack: | |
250 ML | 1 L | ||
10kg | 3 ml | 83 | 333 |
20kg | 6 ml | 41 | 166 |
30kg | 9 ml | 27 | 111 |
40kg | 12 ml | 20 | 83 |
50kg | 15 ml | 16 | 66 |
60kg | 18 ml | 13 | 55 |
70kg | 21 ml | 11 | 47 |
What is coccidiosis?
This Product is only licensed for sale in the Republic of Ireland
Piglets
After oral administration toltrazuril is slowly absorbed with a bioavailability of =70%. The main metabolite is characterised as toltrazuril sulfone. The elimination of toltrazuril is slow with a half-life elimination time around 3 days. The major route of excretion is via the faeces.
Calves
After oral administration in cattle toltrazuril is slowly absorbed. The maximal plasma concentration (Cmax = 36.6 mg/l) was observed between 24 and 48 hours (geometric mean 33.9 hours) following oral administration. The elimination of toltrazuril is slow with a terminal half-life time of approximately 2.5 days (64.2 hours). The main metabolite is characterised as toltrazuril sulfone. The major route of excretion is via the faeces.
Lambs
After oral administration toltrazuril is slowly absorbed in mammals. The main metabolite is characterised as toltrazuril sulfone. The maximal plasma concentration (Cmax = 62 mg/L) was observed 2 days following oral administration. The elimination of toltrazuril is slow with an elimination half-life time of approximately 9 days. The major route of excretion is via the faeces.
Environmental properties
The metabolite of toltrazuril, toltrazuril sulfone (ponazuril) is a persistent (half-life >1 year) and mobile compound and has adverse effects on both the growth and emergence of plants. Given the persistent properties of ponazuril repeated spreading of manure from treated animals may lead to an accumulation in the soil and consequently a risk to plants. The accumulation of ponazuril in soil together with its mobility also leads to a risk of leaching to groundwater.
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