Volume:
Topimec Pour-on for Cattle 0.5% is used for the treatment and control of gastro-intestinal nemotades, lungworms, warbles, chotioptic and sarcoptic mange mites and sucking and biting lice of beef and non-lactating dairy cattle.
Active Ingredient: Ivermectin
Target Species: Cattle
Treats and Controls: Gastro-intestinal roundworms, lungworms, eyeworms, mites and lice
Administration Method: Pour-on
Withdrawal Time: 28 days for animals intended for meat and offal, Not permitted for use on animals producing milk for human consumption. Do not use in non-lactating dairy cows including pregnant dairy heifers within 60 days prior to calving.
Dosage: 1 ml per 10 kg of bodyweight
| Body Weight | Dose Volume | Number of full doses per pack: | ||
| 1 Litre | 2.5 Litre | 5 Liter | ||
| 50kg | 5 ml | 200 | 500 | 1000 |
| 100kg | 10 ml | 100 | 250 | 500 |
| 150kg | 15 ml | 67 | 167 | 333 |
| 200kg | 20 ml | 50 | 125 | 250 |
| 250kg | 25 ml | 40 | 100 | 200 |
| 300kg | 30 ml | 33 | 83 | 167 |
| 350kg | 35 ml | 29 | 71 | 143 |
| 400kg | 40 ml | 25 | 63 | 125 |
| 450kg | 45 ml | 22 | 56 | 111 |
| 500kg | 50 ml | 20 | 50 | 100 |
| 550kg | 55 ml | 18 | 45 | 91 |
| 600kg | 60 ml | 17 | 41 | 83 |
Always read the label and all enclosed information for Topimec Pour-on before administering to animals!
| Signs and effects of infected livestock |
| Infection: Gut Worm
Symptoms: Diarrhoea, decreased appetite, loss of weight Effects: Gutworm can cause severe damage to the stomach and small intestine which will cause parasitic gastroenteritis, this will not only negatively affect the health of the animal but will affect the profitability for the farmer. |
|
Infection: Lungworm Symptoms: Short, sharp cough that becomes worse with exercise, in severe cases the animal will have obvious difficulty breathing. Effects: Lungworm infections cause a high susceptibility to respiratory viruses and bacteria. Infected cattle are prone to contracting severe bronchial pneumonia which if left untreated can lead to death. |
Ivermectin is a semi-synthetic antiparasitic medication derived from avermectins, a class of highly active broad-spectrum antiparasitic agents isolated from the fermentation products of Streptomyces avermitilis.
Ivermectin itself is a mixture of two avermectins, comprising roughly 90% 5-O-demethyl-22,23-dihydroavermectin A1a (22,23-dihydroavermectin B1a) and 10% 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl) avermectin A1a (22,23-dihydroavermectin B1b).
Pharmacodynamics
Ivermectin is a semisynthetic, anthelminitic agent. It is an avermectin, a group of pentacyclic sixteen-membered lactones (i.e., a macrocyclic lactone disaccharide) derived from the soil bacterium Streptomyces avermitilis. Avermectins are potent and broad-spectrum anti-parasitic agents.
Mechanism of action
Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels in invertebrate muscle and nerve cells of the microfilaria.
This binding causes an increase in the permeability of the cell membrane to chloride ions and results in hyperpolarization of the cell, leading to paralysis and death of the parasite.
Ivermectin also is believed to act as an agonist of the neurotransmitter gamma-aminobutyric acid (GABA), thereby disrupting GABA-mediated central nervous system (CNS) neurosynaptic transmission.
Ivermectin may also impair normal intrauterine development of O. volvulus microfilariae and may inhibit their release from the uteri of gravid female worms.
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